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Allergy development to Adequan?

I have a 5 y.o. 1/2 TB mare who has some spurring on both front sesamoid bones that causes joint inflammation and discomfort when consistently worked.

The equine specialist that diagnosed her recommended placing her on a wedge shoe and starting her on Adequan injections. My "regular" vet is ok with the wedge shoe but feels I should start the mare on an oral joint supplement like Grand Flex, Figuerola’s Joint Saver, etc. instead of the injectable Adequan. If, and only if, the oral supplements don’t work, then she would recommend going with the Adequan.

She tells me that vets are finding now that horses are developing allergies to the proteins in Adequan. From what she said, these are horses that had taken Adequan without prior issue for multiple years.

Has anyone else heard of allergy development related to long-term Adequan administration?
*I* am not having allergic issues. The question was related to reports of HORSES developing an allergy to the medication, Adequan, when given to them consistently over a multiple year period.
I know that animals, people, etc. can develop allergies at any time – even to medicines they’ve taken or foods they’ve eaten before. The reason I asked the question is that my vet led me to believe that there was an inordinate number of late-term allergic reactions now being reported. A small percentage is to be expected, but the vet insinuated that it was a growing and significant problem that might indicate we shouldn’t go that route.

The question was answered by :
HorsemanshipQueen :

We have a few horses on Adequan, and have never, ever had a problem with it (and this is like 10+ years).

I would ask a different vet about giving a combination of Adequan/Legend. We’ve found it works wonders for those horses needing a little extra help.

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